Together with Katy Thakkar (Michigan State University) and Vaibhav Diwadkar (Wayne State University), we just wrote an opinion piece on the role of corollary discharge in psychosis, and how prediction in the oculomotor system may help us understand the complex polygenic disorder schizophrenia. The review is going to be published in one of the next issues of Trends in Cognitive Sciences. For now, here is the abstract:

Psychosis—an impaired contact with reality—is a hallmark of schizophrenia. Many psychotic symptoms are associated with disruptions in agency—the sense that I cause my actions. A failure to predict sensory consequences of one’s own actions may underlie agency disturbances. Such predictions rely on corollary discharge (CD) signals, “copies” of movement commands sent to sensory regions prior to action execution. Here, we make a case that the oculomotor system is a promising model for understanding CD in psychosis, building on advances in our understanding of the behavioral and neurophysiological correlates of CD associated with eye movements. We provide an overview of recent evidence for disturbed oculomotor CD in schizophrenia, potentially linking bizarre and disturbing psychotic experiences with basic physiological processes.